Herbs-Phytochemicals: Celastrol From Tripterygium Wilfordii Inhibits Rheumatoid Arthritis Progression By Targeting The COMMD3/8 Complex, Navigating Vascular Complications of COVID-19: An Evolving Understanding and the Road Ahead, Elon Musk Stirs the Crypto Pot: Twitter Bird Replaced with Shiba Inu image, Dogecoin Skyrockets Amid Lawsuit, Scientist From Brazil Find That SARS-CoV-2 Spike Proteins Causes Memory Loss, Metformin and Leucine: A Novel Anti-Aging Tool Combating Muscle Atrophy and Cellular Senescence. BREAKING! BREAKING! BREAKING! This systematic review provides a critical summary of clinical evidence of Krachaidum for all indications. Kaempferia parviflora, the Thai black ginger, Thai ginseng or krachai dum, is an herbaceous plant in the family Zingiberaceae, native to Thailand. COVID-19 News: Study Shows That SARS-CoV-2 Infections Causes Thyroxine Fluctuations. 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In summary, although various indications of Krachaidum were found with varying qualities of evidence, the positive benefits of Krachaidum were reported, and adverse events were not found. COVID-19 News: Study Finds That Non-Omicron Variants More Likely To Cause Damage To The Kidney's Filtration System Than Omicron Sublineages! BREAKING! BREAKING! Study Shows That About 186 American Banks At Risk Of Collapsing, Similar To SVB, Silvergate Capital and Signature Bank Sagas! COVID-19 Treatments: Amino-Acids Cysteine and Theanine Could Have Efficacy Against SARS-CoV-2 According To Japanese Study, BREAKING NEWS! BREAKING NEWS! More Countries Ditching US Dollar. Duration of study varied from 90 minutes31,36 to 4 weeks,35 8 weeks,30,32,34 and 12 weeks.33 Considering outcomes of interest, 4 studies focused on physical or exercise performance,3033 while one each focused on erectile response,34 pain indicators,35 and energy expenditure.36 All studies reported that they used standardized extract of Krachaidum. Infection Rates And Hospitalization Data From South Africa Shows That Omicron Variant Is Indeed Going To Be A Concern! No significant differences between the groups, Significantly increased cardiorespiratory fitness, as indicated by VO, Significantly decreased at week 4 compared with the baseline (both the treatment and placebo groups). Indonesia Remains Unfazed Despite Rising COVID-19 Infections. However, Kaempferia is still included in underutilized plants. COVID-19 News: U.S. NIH Funded Study Discovers That SARS-CoV-2 Spike Protein Binds And Modulates Estrogen Receptors, Increasing Risk Of Thrombosis! Finally! BREAKING! Autopsy Studies By Kings College London Reveal That COVID-19 Is Causing Severe Gastrointestinal Damage Especially On The Ileal Peyerss Patches. French Study Discovers That Autoantibodies Neutralizing Type I Interferons Found Responsible For 20 Percent Of All COVID-19 Deaths! Ohio Study Reveals Startling Link Between Long COVID And Increased Gut Permeability And Oxidized Lipids, Scientists Validate That COVID-19 Causes Microvascular Alteration In Study Using Nailfold Capillaroscopy. However, compared with placebo, no significant additional benefit of Krachaidum on energy expenditure was found (Table 2). Thailand COVID-19 Surge This Time Is Going To Be Devastating While Everyone Is Focused On Economic Recovery, Removal Of Restrictions And Tourism. Hundreds Of Cases Being Brought Up With Thousands More To Come! Source: Thailand Medical NewsOct 21, 20194 years ago. BREAKING! Researchers Find That COVID-19 Infections And Even COVID-19 Vaccines Can Induce Amyloidosis! COVID-19 A Potent Version Of Airborne HIV? BREAKING! BREAKING! BREAKING! Brazil And Sweden Finds Omicron Variant Which Is Now In 19 Countries Outside Of Africa. University of Pennsylvania Scientist Dispels Fallacies and Fake News Generated About Effectiveness Of T-Cells To Combat SARS-CoV-2 After Vaccine Failures! The Looming Threat: Bioterrorism, Gain-of-Function Research, and the Next Global Pandemic Involving A Lab Made Reassortant Strain! New Study Reveals That Melatonin Supplements Can Aid In Treating Certain Long COVID Symptoms, China Locks Down More Zones As COVID-19 Cases Surge. In particular, the ability of KP to regulate cancer cell growth and survival . BREAKING! Clueless Thailand Medical Experts Keep Spewing Out Rubbish In Garbage Mainstream Media That BA.2 Is Mild And That Long COVID Resolves In Three Months! BREAKING! Wuhan Study Shows That Glutamine And Pyruvate Supplementation, Also Rosiglitazone Can Reduce And Prevent Hyperinflammation In COVID-19! Preliminary Studies Now Show That B.1.1.529 is about 500 Times More Infectious Than Delta And Has About 2 to 3 Furin Cleavage Sites! Strategic search terms included Kaempferia parviflora, Black ginger, Krachaidum (a Thai word for Kaempferia parviflora), or other synonym names. COVID-19 Latest: US Study Shows Co-Infection With Two Different Strains Of SARS-COV-2 Is More Deadly And More Such Cases Emerging Globally, BREAKING NEWS! A Multicenter Cohort Study Finds That Doxycycline Helps In Reducing Thrombosis and Mortality in Critically Ill Patients With COVID-19. Two British Studies Say That Omicron Results In Lower Disease Severity And Hospitalizations. New Zealand Reports 14,657 New COVID-19 Cases For The Last 7 Days And 43 COVID-19 Deaths Amidst An Onslaught By A variety Of XBB Sublineages, Romanian Study Shows That Arginine Supplements Can Help With Post-COVID Fatigue, Unmasking The Antiviral Role Of CD56+ T Cells In COVID-19. BREAKING! Kaempferia parviflora and Its Methoxyflavones: Chemistry and - Hindawi Austrian Study Warns Many Post COVID-19 Individuals Sustain Persistent Systemic Inflammation That Causes Structural And Functional Lung Abnormality! BREAKING! Second Day COVID-19 Cases Exceeding 20,000 As Measures Eased, German Study Shows That Short-Chain Fatty Acids (SCFAs) Can Treat Inflamm-Aging And Acute Lung Injury In The Old, Four Symptoms That Are Red Flags For Early-Onset Colorectal Cancer, The Intriguing Link Between Xanthines And Immune Cell Differentiation In The Gut, Dietary Fisetin And Fisetin Supplements Emerging As Promising Therapeutic Agents For Antiaging and Longevity. The Omicron Is Evolving Rapidly And Big Pharma Is Providing Opportunities For It To Do So! Two authors (SS and PW) independently scanned all the titles and abstracts to determine whether the studies assessed the clinical effects of Krachaidum. BREAKING! COVID-19 Study Reveals That SARS-CoV-2 Uses CD4 Cells To Infect T-helper Lymphocytes. Urgent Studies Warranted! Then, 3 treatment groups were orally administered with Krachaidum extract at doses of 5, 50, and 500 mg/kg/day for 6 months, respectively, which were equivalent to 1, 10, and 100 times that of human use, while 2 control groups were orally given distilled water and 1.0% tragacanth, respectively. Oops! Kaempferia parviflora has been the subject of increased scientific interest in recent years. AI In Medicine: Revolutionizing Brain Cancer Treatment-Cutting-Edge AI System Deciphers Tumor Genetics in Lightning-Fast 90 Seconds! COVID-19 News: More Case Reports Emerging Of COVID-19 Patients Manifesting Pneumomediastinum Or Mediastinal Emphysema! South Korean Study Validates That SARS-CoV-2 Can Remain Viable On Foods For A Long Time Depending On Storage Temperatures. SARS-CoV-2 XBB Recombinant Variant Spawning Newer Sub-Lineages Such As XBB.1, XBB.1.1, XBB1.2, XBB.2, XBB.3, XBB.3.1, XBB.4 and XBB.5! 231,000 COVID-19 Cases, 498 Deaths In Last 24 Hours! Biofunctional properties and plant physiology of Kaempferia spp Re-infections Are Going To Be Common In 2022! U.S. Study Shows That Upper-Room Germicidal Ultraviolet-C Irradiation (UR GUV) Devices Effective in Eradicating Aerosolized SARS-CoV-2 In Enclosed Areas. Vancouver Health Authorities Warn About Outbreak Of Haemophilus Influenza Type B (Hib) Disease, A Bacterial Infection. SARS-CoV-2 Infections Causes Intestinal Ischemia That Increases Disease Severity And Risk Of Mortality! K. parviflora has been used as a herbal product in a variety of preparations, including fresh or dried rhizomes, dried powder in tea bags, and wine. COVID-19 News: Numerous Studies And Emerging Data Are Warning That Strokes And Heart Failures Are A Serious Threat For Post COVID Individuals! COVID-19 News: Canadian Study Finds That SARS-CoV-2 NSP5 Prevents And Delays Viral Clearance By Antagonizing The MHC II Antigen Presentation Pathway! We herein evaluated the effects of KPE on physical . Plant-Based Compound Dicoumarol Emerges as Promising Post-Exposure Prophylactic For Omicron Variant Of SARS-CoV-2, Polish Study Reveals That SARS-CoV-2 Impairs Human Natural Killer (NK) Cells Through The Activation Of The LLT1-CD161 Axis, Unveiling The Intriguing Mechanism of SARS-CoV-2's Most Toxic Accessory Protein: ORF6 Sheds Light On COVID-19 Pathogenesis. COVID-19 News: Chinas COVID-19 Crisis Is Going To Hit The West Hard. SARS-CoV-2 Research: ORF6 And NSP13 Proteins Cause Degradation Of The DNA Damage Response Kinase CHK1 Through Proteasome And Autophagy. The https:// ensures that you are connecting to the U.S. Clinical Trial Shows That Probiotics Like Lactobacillus Rhamnosus GG Can Reduce COVID-19 Symptoms When Taken As A Post-Exposure Prophylaxis. BREAKING! BREAKING! Forest plot illustrating the effect of Krachaidum on hand grip strength. SARS-CoV-2 Causes Thymic Dysregulation And Thymic Atrophy That Results In Lymphopenia And Peripheral T Cell Receptor Repertoire Changes! BREAKING! Scientist Discover That SARS-CoV-2 Also Has A PCSK9 Cleavage Site! SARS-CoV-2 Research: Vietnamese Researchers Discover That SARS-CoV-2 Nsp1 Proteins Bind To Ribosome 40S Subunits, Inhibiting mRNA Translation! Mites That Cause Scabies Are Now Evolving To Evade Standard Treatments Involving Permethrin! BREAKING! LATEST! Kaempferia - an overview | ScienceDirect Topics XBB.1.16 And XBC.1.6 Expected To Lead New Onslaughts. Locals Nicknaming It The Hantu Besar Variant! WHO Warns That Infertility Rates Are Rising With 17.5 Percent Of Individuals Globally Infertile! 2,106 New COVID-19 on Friday, Active Cases Now 16,577, Highest In Nearly 5 Months, Regulation of Intestinal Treg Cells Differentiation: The Crucial Role of Intracellular Iron Uptake Facilitated by the Gut Microbiome. Long COVID News: Cambridge Study Shows Persistent T-Cell Dependent Interferon Gamma Release In Individuals Who Develop Long COVID. Kaempferia parviflora In addition, KPE also improved lactic acid metabolism, mitochondrial numbers, and the accumulation of muscular glycogens in C2C12 myoblasts. Brazilian Respiratory Expert Says That COVID-19 Should Be Treated As A Thrombotic Disease, WARNING! Co-Infections Involving COVID-19 With Flu Or Cold Viruses Like RSV or Adenovirus Doubles The Risk Of Dying! BREAKING! Is The Current RVS Wave Due To Newly Emerged Strains? University Of Glasgow Discovers New Pathogen That Can Evade Immune System Comprising Of Fused RSV And Influenza Virus Particles! COVID-19 News: Chinese Government Scientists Upload Vast Number Of Sequences On GISAID That Shows Only Ordinary SARS-CoV-2 Variants! COVID-19 Research: SARS-CoV-2 Infection Causes Alterations In Gut Immunological Barrier! The World Is Under Attack By The Omicron, New Delta Subvariants, New Omicron Sub-lineages And Recombinant Strains! BREAKING! COVID-19 News: Spanish Researchers Warn That SARS-CoV-2 Infections And Vaccinations Trigger Reactivation Of All Kinds Of Herpesviridae Viruses! Risk of bias: (A) Risk of bias in each study; (B) Summary risk of bias of included studies. Brazilian Study Reveals That Usage Of Antiparasitic Drug, Ivermectin Can Lead To Gut Dysbiosis and Liver Damage! Was The Marburg Virus Outbreak In Equatorial Guinea Real? Accessibility BREAKING! BREAKING! COVID-19 Drugs: US FDA Drug Trial Concludes That Most Drugs Being Used Including Favipiravir, Lopinavir, Ritonavir, Chloroquine Has No Effects On COVID-19, Covid-19 Research Updates: Chinese Study Reveals That Hypokalemia Present In Almost All Covid-19 Patients. On the contrary, comparing with analgesic cream, Krachaidum cream showed nonsignificant different (Table 2). Australian Study Warns That Nose Picking or Plucking Nose Hairs Can Lead Increased Risk for Alzheimers Disease and Dementia! UCLA Scientists Discover That Incorporating SARS-CoV-2 Viral Polymerase Protein In Vaccines Can Elicit Better T Cell Response And Make Vaccines Better, BREAKING! In a systematic review in 2016, 683 records and 7 studies were analyzed, with a reference that krachai dum significantly increased hand grip strength and enhanced the response to sexual erotic stimuli. Omicron Has Shifted To Using Cathepsins For Cell Entry Via Endosomal Fusion, Impacting Cellular Tropism And Pathogenesis! Chinas Scientists Say Omicron Most Probably Originated From A Mouse And Not From A Human Host! Concealing Data? BREAKING! BREAKING News! Zika Virus News: Hungary Authorities Report That Two Individuals Returning After A Holiday Trip To Thailand Test Positive For Zika Virus! BREAKING MEDICAL NEWS! BREAKING NEWS! ALL RV/RS And PW Exponents And Members Of Project NA, Urgent Online Meetup At 1500HRS New York Time Today! Explosive New U.S. Report Unveils Shocking COVID-19 Origins: Two Lab Leaks and a Secret Vaccine! Study Discovers That Unfolded Protein Response Components IRE1 And XBP1 Play Key Roles In Human Coronavirus Infections Including SARS-CoV-2! Omicron Strikes Again, Infecting the Same Person Just 16 Days Apart! TheK. Mutations On Omicron Non-Structural Protein 6 (Nsp6) Alters Viral Disruption Modes Of Autophagy In Host, Leading To Possibly More Serious Long Term Issues! Nathorn Chaiyakunapruk, PharmD, PhD, School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 46150 Bandar Sunway, Selangor 47500, Malaysia. Stanford-Yale Study Shows Even Mild SARS-CoV-2 Infection Can Cause Multi-Lineage Cellular Dysregulation And Myelin Loss In The Brain! Studies in which baseline characteristics were different among study groups or not tested for their difference were considered as high risk for the domain of other risk of bias. Each study was classified as having low risk (low risk of bias for all key domains), high risk (high risk of bias for one or more key domains), or unclear risk (unclear risk of bias for one or more key domains). Canadian Study Reveals That Majority Of Non-Hospitalized COVID-19 Infected Individuals Have Decreased Cerebral Blood Flow! They found that Krachaidum at a dose of 90 mg/day significantly decreased the response latency time to sexual erotic stimulation and still showed significant changes during the delay period. parviflora extract (KPE) was previously reported to have a number of physiological effects; however, the antiobesity effects of KPE and its mechanisms remain to be elucidated. MIT Study Shows That Long COVID Neurological Issues Is Due To Delayed Clearance Of SAR-CoV-2 Caused By Immune Imprinting! Important Notice To Researchers- Kindly Specify SARS-CoV-2 Variant Type Used When Publishing In Vitro, Vivo or Clinical Studies On Prophylactics or Therapeutics Agents, Study Shows Potential Of Combining Iota-Carrageenan And Xylitol As A Potential Prophylactic Nasal Spray For COVID-19. Many Thais Still Oblivious Of Dangers! Outbreak News: Murray Valley Encephalitis Virus Reemerges Back In Victoria, Australia After 49 Years! Shocking Revelation For Transgenders: Study Confirms Transgender Women Are Also At Risk for Prostate Cancer - They Are Not Really Women After All! New Zealand Led Study Finds That Omega-3 Fatty Acids Are Useful In Treating COVID-19 Associated Cardiovascular Issues, Brazilian Study Validates That COVID-19 Infections Also Affects The Musculoskeletal System. Of the remaining 462 records, 378 were deemed ineligible based on title and abstract. Scientists Warn That Imprinted SARS-CoV-2 Humoral Immunity Is Inducing Convergent Omicron RBD Evolution At An Unprecedented Rate! BREAKING! 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News-COVID-19: Study Shows That SARS-CoV-2 Can Bind To Human Host Neuropilin-1 Receptor (NRP-1), Blocking Certain Pain Signals In Host! In the specific tribes in Thailand, Kaempferia parviflora, a Zingiberaceae plant, has been used a folk medicine called "Krachai Dum."The rhizome and tincture of K. parviflora has been applied as medicine for general pain, colic gastrointestinal . Author Contributions: SS, PD, and NC conceptualized the study and developed the inclusion criteria. Fumarate Hydratase Discovered As An Enzyme That Holds The Key To Treating Inflammatory Diseases Such As Lupus, Arthritis, Sepsis And COVID-19! University Of Oxford Study Shockingly Finds That Lungs of Post COVID-19 Individuals Displayed Premature Aging Of More Than 15 Years! Study Finds That Cannabis Use Disorder In Young Males Leads To Higher Risk Of Developing Schizophrenia! Black Ginger (Kaempferia parviflora) Extract Enhances Endurance Scientists Shocked by Unprecedented Reinfections! 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Studies Reveal That All Coronaviruses Deploy Papain-Like Proteases With Deubiquitinating And DeISGylating Activity To Evade Immune Responses! One Out Of 25 In The UK Who Test Positive For COVID-19 Typically Dies Within 28 Days! BREAKING! With More Than 300 New Variants Now In Circulation, Urgent Need To Introduce Mandatory Genomic Sequencing Of All SARS-CoV-2 Infections. It Might Not Even Be XBB.1.9.1 Or the New XBB.1.16 Sublineage Driving The New Onslaught In India But Something Not Identified Yet! Only one randomized controlled trial compared Krachaidum with placebo in human subjects on erectile response.34 Subjects receiving Krachaidum 25 mg/day (n = 15), or 90 mg/day (n = 15), were compared with those receiving placebo (n = 15) for 8 weeks of study period. Dutch And German Study Shows That SARS-CoV-2 Directly Infects The Kidneys And Causes Tissue Scarring Which Ultimately Leads To Kidney Damage And Failure! Antihistamines Help, BREAKING NEWS! Medical Warnings: BEWARE! Misdiagnosis Of Cocaine Induced Nasal Damage As An Innocuous Disease Could Be Life-Threatening, Reveals Study On Granulomatosis With Polyangiitis. COVID-19 Drug Strategies Have Been Wrong! Comparing with baseline, the results in both groups showed significantly reduce pain in all indicators at 4 weeks. ProMED Says It Is Fake News But More Reports Emerging! Sci. Long-COVID and Autoimmune Disease Risk: The Invisible Scourge Unleashed by COVID-19. The main findings from 2 studies30,31 indicated that Krachaidum showed no acute improvement in either repeated sprint performance or endurance exercise. BREAKING! AI-Based Tool Identifies Myosteatosis As A New Silent Killer In Many Asymptomatic Adults! From the included clinical trials, the benefits of Krachaidum remained inconclusive. Omicron Mild?
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