Bolognia J.L., Schaffer J.V., Cerroni L., editors. Significant clinical improvement was observed after 2 months of therapy. sharing sensitive information, make sure youre on a federal Aluminum granuloma after administration of the quadrivalent human In addition, the key role Th17 and Th22 axes and the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway were upregulated [29]. eCollection 2022. There have been case reports associating the administration of a vaccine with the new onset of a dermatologic condition, such as lichen planus, granuloma annulare, and Sweet syndrome. Bethesda, MD 20894, Web Policies Granuloma annulare often appears after people injure their skin. The patient is under constant routine follow-up and is well and without lesions. -. Careers. Before This additional case, like what happens after the administration of other vaccines, supports the idea that GA may result from the immune system activation following the vaccination. The phase IV clinical study analyzes which people get Pfizer BioNTech Covid Vaccine and have Granuloma annulare. The exaggerated inflammatory response is linked to the triggering of innate and adaptive immune responses and to the monocytic-macrophage system [22]. Unauthorized use of these marks is strictly prohibited. See this image and copyright information in PMC. Skin findings on initial visit with erythematous papules with central clearing coalescing into annular plaques on the breasts, lower portion of the back, flanks, and inguinal folds. sharing sensitive information, make sure youre on a federal Fig. The site is secure. Penas P.F., Jones-Caballero M., Fraga J., Snchez-Prez J., Garca-Dez A. Perforating granuloma annulare. 2023 Apr;12(2):87-96. doi: 10.7774/cevr.2023.12.2.87. The site is secure. Would you like email updates of new search results? As discussed by Akinosoglou etal,7 there has been a well-established correlation with hyperactivation of the immune system, resulting in an inordinate cytokine release that led to multiorgan failure and death in patients with COVID-19. The https:// ensures that you are connecting to the Anyway, colleagues should encourage patients to obtain the vaccination in order to assist the public health systems to overcome the COVID-19 pandemic. FOIA 1B). A 69-year-old woman developed a single reddish lesion on the left deltoid region, where the SARS-CoV-2 vaccine seven days earlier was injected. Before the contents by NLM or the National Institutes of Health. Epub 2022 Mar 5. government site. Copyright 2020 Sociedade Brasileira de Dermatologia. A 69-year-old woman developed a single reddish lesion on the left deltoid region, where the SARS-CoV-2 vaccine seven days earlier was injected. When interferon tiptoes through SARS-COV-2: Pernio-like lesions and their prognostic implications during SARS-CoV-2 infection. PMC The .gov means its official. The patient was instructed to continue her current treatment, and hydroxyzine 25mg every night at bedtime was prescribed. Authors Derek K Marsee 1 , John M Williams, Elsa F Velazquez Affiliation The third patient was a 63-year-old male with abrupt onset, multiple, asymptomatic, skin-colored to erythematous nodules involving abdomen, bilateral upper and lower limb, arising twenty days after a positive rapid antigen test for SARS-Cov-2. Please enable it to take advantage of the complete set of features! Akinosoglou K., Tzivaki I., Marangos M. Covid-19 vaccine and autoimmunity: awakening the sleeping dragon. 2023 Apr 20;48(1):10-12. -. At followup 2months later, there was a reduction and flattening of the skin lesions (Fig 3). Dermatol. Inclusion in an NLM database does not imply endorsement of, or agreement with, The https:// ensures that you are connecting to the Generalized granuloma annulare after pneumococcal vaccination. - Europe PMC Unable to load your collection due to an error, Unable to load your delegates due to an error. Granuloma annulare triggered by SARS-CoV-2 infection. Please enable it to take advantage of the complete set of features! 2016;75(3):457465. Avallone G., Quaglino P., Cavallo F., Roccuzzo G., Ribero S., Zalaudek I., Conforti C. SARS-CoV-2 vaccine-related cutaneous manifestations: asystematic review. Histology showed an interstitial GA [5]. Skin manifestations in patients with coronavirus disease 2019. Introduction: Houcke-Bruge C, Delaporte E, Catteau B, Martin De Lassalle E, Piette F. Ann Dermatol Venereol. Clinical and histological features of post-Cov-19-infection and post-SARS-Cov-2 vaccination GA patients. 2006 Nov 15;74(10):1729-34. Among these are vaccinations, which have been described as an infrequent cause of granuloma annulare. An official website of the United States government. To our knowledge, our case is the first reported in the literature of generalized GA occurring after COVID-19 vaccination. All information is observation-only. HE 4 (A: Patient; B: Control1; C: Control2): at low power view, the three biopsies show the same type of lesion, with granulomatous pattern and necrobiotic changes. It appears as one or more self-regressing erythematous papules that tend to form annular or arciform plaques, localized mainly on the dorsum of hands and feet or over the trunk. Huynh T., Sanchez-Flores X., Yau J., Huang J.T. Accessibility Keywords: and transmitted securely. Bethesda, MD 20894, Web Policies Before The authors documented the clinical and histopathological features of an unexpected case of granuloma annulare (GA) arising a few days after the SARS-CoV-2 vaccination and reviewed all GAs reported in the literature following the SARS-CoV-2 vaccination and Cov-19-infection. National Library of Medicine 2005;19:639640. In dermatopathological practice, it should be aware of the . Monte-Serrano J., Garca-Gil M.F., Garca-Garca M., Casas-Flecha I., Matovelle-Ochoa C., Ara-Martn M. Granuloma annulare triggered by SARS-CoV-2 infection: immunohistochemical staining. Granuloma Annulare - Symptoms, Causes, Treatment | NORD Trials. Epub 2023 Apr 30. The inflammatory cell infiltrate interspersed between the collagen fibers (haematoxylin and eosin,, MeSH Bookshelf An annular, irregular, sharply demarcated, pink-colored erythematous papular lesion, Multiple, asymptomatic, skin-colored to erythematous nodules. HHS Vulnerability Disclosure, Help The https:// ensures that you are connecting to the Generalized granuloma annulare after COVID-19 vaccination Emre S., Unal E., Celik B., Sungu N. The case of granuloma annulare associated with SARS-CoV-2 infection. Careers. Vaccinations are important to promote development of both individual and herd immunity. Clin Exp Dermatol. Wolf F, Grezard P, Berard F, Clavel G, Perrot H. Houcke-Bruge C, Delaporte E, Catteau B, Martin De Lassalle E, Piette F. Ann Dermatol Venereol. 2021;96(1):5963. At dermoscopy, linear arborizing vessels, A. Generalized granuloma annulare after COVID-19 vaccination Introduction. Would you like email updates of new search results? Case report: Aluminum granuloma after administration of the quadrivalent human papillomavirus vaccine. COVID-19 vaccination, disseminated granuloma annulare, granuloma annulare, vaccine reaction. Kakurai M., Kiyosawa T., Ohtsuki M., Nakagawa H. Multiple lesions of granuloma annulare following BCG vaccination: case report and review of the literature. A. Generalized granuloma annulare after COVID-19 vaccination Vojdani A., Kharrazian D. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Bookshelf Granuloma annulare is a chronic degenerative skin disorder. Before Our patient has a history of hyperlipidemia, which, along with diabetes, has been cited as a likely risk factor for GA; however, more studies are needed to better substantiate this relationship.3,4 To our knowledge, no studies have evaluated the time sequence between dyslipidemia and the onset of generalized GA. Dyslipidemia was considered as a possible etiology; however, given her 10-year history of hyperlipidemia and treatment with a statin, we concluded that the presentation of generalized GA 2weeks after COVID-19 vaccination was more likely attributed to the vaccination rather than the hyperlipidemia. Generalized granuloma annulare in infancy following bacillus Calmette-Gurin vaccination. Granuloma annulare (GA) is a benign skin reaction with an incidence of 0.04% in the US, and has shown to be significantly associated with autoimmune disease, diabetes mellitus, and hyperlipidemia. Criado P.R., Pagliari C., Carneiro F.R.O., Quaresma J.A.S. In detail, the first patient was a 53 years-old woman with an annular lesion on the second finger on the left hand and a papule on the knuckle of the same finger, arising at the same time with the onset of SARS-CoV-2 typical symptoms (dysgeusia, anosmia and headache) and a positive real-time polymerase chain reaction (RT-PCR) test for SARS-CoV-2. Pfizer BioNTech Covid Vaccine and Granuloma annulare - eHealthMe In 2021, Monte-Serrano etal6 described a patient who developed localized GA after SARS-CoV-2 infection. The site is secure. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. 2011;23(Suppl 3):S31921. Association of granuloma annulare with type 2 diabetes, hyperlipidemia, autoimmune disorders, and hematologic malignant neoplasms. Some are directly related to the injection of a live attenuated virus, such as varicella or vaccinia (for immunity to smallpox), whereas others cause more nonspecific erythema and swelling at the injection site, as a result of local inflammation or irritation. Dermoscopy revealed linear arborizing vessels on a whitish-red background (Fig. Cutaneous reaction, Granuloma annulare, COVID-19 pandemic, SARS-CoV-2 vaccination. 2022 Apr;232:153834. doi: 10.1016/j.prp.2022.153834. A randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the efficacy and safety of SARS-CoV-2 vaccine (inactivated, Vero cell): a structured summary of a study protocol for a randomised controlled trial. Accessibility Granuloma annulare may be caused by multiple triggers. Clipboard, Search History, and several other advanced features are temporarily unavailable. The etiology of GA is unknown but is postulated to be a delayed-type hypersensitivity to a stimulus.1,4,5 There have been several associations with generalized GA, including diabetes mellitus, malignancy, thyroid disease, dyslipidemia, HIV, and hepatitis B and C. Generalized GA has a prolonged course that is poorly responsive to treatment and comprises 8% to 15% of all cases.5 Of the 13 cases of vaccine-induced GA in the literature, 8 occurred after the bacillus Calmette-Gurin vaccine, and none were reported to develop after administration of the COVID-19 vaccine.2 Seventy-six percent of all cases described to occur after vaccination have represented the generalized form of GA and, on average, presented within 8weeks following vaccination.2, Amidst the COVID-19 pandemic, there have been several cases of GA occurring shorty after infection with the SARS-CoV-2. eCollection 2022. Although uncertain etiology, it could represent a hypersensitivity reaction to triggers such as trauma, medications, malignancy, viral infections, and vaccinations [2]. An official website of the United States government. 2A-D). Granuloma annulare in Moderna COVID Vaccine, Granuloma annulare in Johnson & Johnson COVID Vaccine, Abortion spontaneous (naturally occurring miscarriage), Acute myocardial infarction (acute heart attack), Acute upper airway obstruction (blockage occurs in the upper airway), Ageusia (loss of taste functions of the tongue), Agitation (state of anxiety or nervous excitement), Alopecia areata (patchy baldness that typically begins with rapid hair loss), Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death), Angioedema (rapid swelling of the dermis), Appendicitis (inflammation of the appendix), Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat), Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires), Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system), Arthritis (form of joint disorder that involves inflammation of one or more joints), Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem), Atelectasis (partial or complete collapse of the lung), Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles), Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue), Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis), Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones), Belching (release of gas from the digestive tract), Blindness transient (sudden loss of vision), Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure), Blood thyroid stimulating hormone decreased, Blood thyroid stimulating hormone increased, Bradycardia (abnormally slow heart action), Breast lump (localized swelling that feels different from the surrounding breast tissue), Bronchitis (inflammation of the mucous membrane in the bronchial tubes), Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle), Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder), Canker sores (painful, open sore in the mouth), Cardiomyopathy (weakening of the heart muscle), Cardio-respiratory arrest (sudden dysfunction of heart and lungs), Cerebral haemorrhage (bleeding within the brain), Cerebral infarction (less blood supply to brain resulting tissue damage), Cerebral thrombosis (blood clot in brain), Chapped lips (cracking, fissuring, and peeling of the skin f lip), Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe), Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving), Concussion (short loss of normal brain function in response to a head injury), Coronary artery occlusion (complete obstruction of blood flow in a coronary artery), Coronary heart disease (narrowing or blockage of the coronary arteries), Crohn's disease (condition that causes inflammation of the gastrointestinal tract), Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis), Dehydration (dryness resulting from the removal of water), Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it), Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens), Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies), Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall), Drooling (drop saliva uncontrollably from the mouth), Dyskinesia (abnormality or impairment of voluntary movement), Ear pruritus (pruritus or itching is ""the unpleasant skin sensation that frequently provokes scratching"" in ear), Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters), Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat), Ejection fraction decreased (systolic heart failure), Encephalopathy (functioning of the brain is affected by some agent or condition), Euphoric mood (excessively happy but may become angry or irritable), Eyelid ptosis (falling of the upper or lower eyelid), Eyelid twitch (spontaneous and uncontrolled spasms of the muscles), Facial paralysis (loss of function of face muscle), Facial paresis (weakness in facial muscle movement), Fainting (loss of consciousness and postural tone), Feeding disorder (when children refuse to eat certain food groups), Fibromyalgia (a long-term condition which causes pain all over the body), Flank pain (a distressing sensation experienced around the lower back and the upper abdomen), Flatulence (flatus expelled through the anus), Fluid retention (an abnormal accumulation of fluid in the blood), Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin), Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus), Gastrointestinal disorder (functional problems of gastrointestinal tract), Gastrointestinal haemorrhage (bleeding gastrointestinal tract), Gaze palsy (disorders affecting the ability to move both eyes in the same direction), General physical health deterioration (weak health status), Glossodynia (a burning or painful sensation in the tongue), Gout (uric acid crystals building up in the body), Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system), Haematochezia (passage of stools containing blood), Haematoma (collection of blood outside the blood vessels), Hallucinations (sensations that appear real but are created by your mind), Heart palpitations (feelings or sensations that your heart is pounding or racing), Hemiparesis (weakness on one side of the body), Hemiplegia (paralysis of one side of the body), Herpes simplex (herpes simplex is a common viral infection), Hyperacusis (disorder in loudness perception), Hyperhidrosis (abnormally increased sweating), Hyperkalemia (damage to or disease of the kidney), Hyperthyroidism (over activity of the thyroid gland), Hypervolaemia (abnormally increased volume of blood), Hypoaesthesia (reduced sense of touch or sensation), Hypoaesthesia oral (reduced sense of touch or sensation in mouth), Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration), Hyporesponsive to stimuli (abnormally low degree of responsiveness on an agent, action, or condition), Hypotension (abnormally low blood pressure), Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development), Idiopathic pulmonary fibrosis (chronic lung disease), Incoherent (talking in a confused and unclear way), Incontinence (lack of moderation or self-control), Injection site erythema (redness at injection site), Injection site haemorrhage (bleeding from injection site), Injection site nodule (small swelling or aggregation of cells in the body, esp.
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